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. 2022 Dec 13;13:1018761. doi: 10.3389/fphar.2022.1018761

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Copyright © 2022 Lodi, Gentili, Casciano, Romani, Zauli, Secchiero, Zauli, Simioni, Beltrami, Fernandez, Rizzo and Voltan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MDM2 inhibitors activate p53 pathway in alveolar basal epithelial cells. Western blotting analysis of p53, MDM2 and Rb proteins in A549-hACE2 cell cultures treated with different concentrations of Nutlin-3 (A,C,E) or RG-7112 (B,D,F) and relative controls (Unt, untreated; DMSO, control vehicle). Protein levels were evaluated 24 h after treatments (A,B) and 48 h after SARS-CoV-2 infection (corresponding to 72 h after initial treatment) in infected (C,D) and mock cultures (E,F). Images are representative of three independent experiments. β-tubulin is used as internal control.

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