TABLE 1.

S. mansoni parasite burden and pathology in mice^a

Mouse genotype	Mean no. of worm pairs/mouse ± SEM	Mean no. of eggs/liver ± SEM	Mean granuloma diamb (μm) ± SEM
WT	11 ± 1.2	17,797 ± 2,696	216 ± 15.7
IL-4−/−	12 ± 1.9	22,160 ± 3,954	220 ± 12.0
IL-12−/−	14 ± 1.8	19,604 ± 2,590	198 ± 8.2
IL4/12−/−	12 ± 1.6	19,178 ± 3,076	211 ± 21.0

^aMice were infected with approximately 70 cercariae each, and there were five animals per group. 

^bMeasurements were obtained by using an ocular micrometer to determine the diameter of the granulomatous lesion around a single egg containing a mature embryo. Twenty granulomas were measured per liver.