Table 3.
Selected SNPs used for studying thermotolerance adaptation genes in various sheep breeds.
| SNP | Locus | Gene name | Allele substitution | Chromosome | |
|---|---|---|---|---|---|
| 1 | rs593507294 | LEP | Leptin | C/T | 4 |
| 2 | rs161110765 | SOCS3 | Suppressor of cytokine signalling 3 | A/C | 11 |
| 3 | rs161286575 | PPARG | Peroxisome proliferator-activated receptor gamma | C/T | 19 |
| 4 | rs603870279 | ASIP | Agouti signalling protein | C/T | 13 |
| 5 | rs598380853 | ASIP | Agouti signalling protein | C/G | 13 |
| 6 | rs601650611 | ASIP | Agouti signalling protein | C/G | 13 |
| 7 | rs420959261 | CSN1S1 | Casein alpha s1 | C/T | 6 |
| 8 | rs587905107 | CSN1S1 | Casein alpha s1 | C/T | 6 |
| 9 | rs416941267 | CSN2 | Casein beta | G/T | 6 |
| 10 | rs430298704 | CSN2 | Casein beta | C/T | 6 |
| 11 | rs420611298 | ABCG1 | ATP binding cassette subfamily G member 1 | G/T | 1 |
| 12 | rs159956881 | ABCG2 | ATP binding cassette subfamily G member 1 | A/G | 6 |
| 13 | rs159876394 | IGF1 | Insulin like growth factor 1 | C/G | 3 |
| 14 | rs160257833 | ESR1 | Oestrogen receptor 1 | A/G | 8 |
| 15 | rs591182158 | ESR1 | Oestrogen receptor 1 | A/G | 8 |
| 16 | rs598908205 | GNRH1 | Gonadotropin releasing hormone 1 | C/T | 2 |
| 17 | rs411181557 | DIO2 | Deiodinase iodothyronine type II | C/G | 7 |
| 18 | rs414917134 | BTNL2 | Butyrophilin like 2 | C/G | 20 |
| 19 | rs405270595 | BTN1A1 | Butyrophilin | A/G | 20 |
| 20 | rs161146164 | GHR | Growth hormone receptor | G/T | 16 |
| 21 | rs55631463 | GHR | Growth hormone receptor | A/G | 16 |
| 22 | rs407318935 | STAT1 | Signal transducer and activator of transcription 1 | A/G | 2 |
| 23 | rs161691559 | HSP90AB1 | Heat shock protein 90 alpha family class B member 1 | A/G | 20 |
| 24 | rs397514115 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | G/C | 18 |
| 25 | rs397514116 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | C/G | 18 |
| 26 | rs397514117 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | A/C | 18 |
| 27 | rs397514269 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | A/G | 18 |
| 28 | rs397514270 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | G/T | 18 |
| 29 | rs397514271 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | A/G | 18 |
| 30 | rs397514268 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | -/G | 18 |
| 31 | rs397514272 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | G/T | 18 |
| 32 | rs397514273 | HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | A/G | 18 |
| 33 | rs588145625 | HSPA8 | Heat shock protein family A member 8 | A/G | 15 |
| 34 | rs161504783 | HSPA12A | Heat shock protein family A member 12A | C/T | 22 |
| 35 | rs160077209 | HSPA4 | Heat shock protein family A member 4 | A/G | 5 |
| 36 | rs589164764 | IL1R1 | Interleukin 1 receptor type 1 | C/T | 3 |
| 37 | rs160387232 | IL1R1 | Interleukin 1 receptor type 1 | C/T | 3 |
| 38 | rs590620426 | IL2 | Interleukin 2 | C/G | 17 |
| 39 | rs596312311 | IL2 | Interleukin 2 | C/T | 17 |
| 40 | rs416425182 | TR | Thyroglobulin | A/C | 9 |
| 41 | rs595200178 | TR | Thyroglobulin | A/G | 9 |
| 42 | rs418400798 | TR | Thyroglobulin | C/T | 9 |
| 43 | rs410259751 | IL33 | Interleukin 33 | G/T | 2 |
| 44 | rs162295351 | HSP90AB1 | Heat shock protein 90 alpha family class B member 1 | A/C | 20 |
| 45 | rs161691552 | HSP90AB1 | Heat shock protein 90 alpha family class B member 1 | A/G | 20 |
| 46 | rs597293577 | STAT_PIAS3 | Protein inhibitor of activated STAT, 3 | C/T | 1 |
| 47 | rs593155540 | STAT_PIAS3 | Protein inhibitor of activated STAT, 3 | A/G | 1 |
| 48 | rs602521720 | HCRT | Hypocretin neuropeptide precursor | C/G | 11 |
| 49 | rs425706327 | USP19 | Ubiquitin specific peptidase 19 | A/G | 19 |
| 50 | rs161274296 | USP19 | Ubiquitin specific peptidase 19 | G/T | 19 |
| 51 | rs588498137 | STAT3 | Signal transducer and activator of transcription 3 | A/G | 11 |