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. 2022 Dec 16;24:136–152. doi: 10.1016/j.bioactmat.2022.12.010

Fig. 2.

Fig. 2

Three-in-one nano-micelle-mediated tumor priming, tumor optical imaging and neoadjuvant chemotherapy. a. Scheme of 3-in-1 PEG-b-PLA nanoparticles containing PTX/17-AAG/RAPA, and diagram of DIR containing PEC-b-PCL micelles. b. Schematic illustration of PTX/17-AAG/RAPA nano-micelle-mediated tumor priming and subsequently promoted NIR optical imaging of tumor by DiR loaded PEC-b-PCL micelles. c. In vivo NIR imaging of tumor bearing mice after administering DiR-containing PEG-b-PCL micelles following vehicle, PTX, and PTX/17-AAG/RAPA injection for 48 h. d. Intratumoral distribution of DiR-containing PEG-b-PCL micelles in different treatment groups. e. Apoptotic cells in tumor tissue of different treatment groups. f. Tumor growth curve in different treatment groups. g. Mice body weight in different treatment groups [32]. Copyright 2011. American Chemical.