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. 2022 Dec 13;16:1031448. doi: 10.3389/fninf.2022.1031448

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Copyright © 2022 Siddique, Awan, Nabi, Khan and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chronic jetlag (CJL) disrupts serotonin regulation in the brain. (A) CJL altered the levels of 5-HT receptors and transporters in the nucleus accumbens and prefrontal cortex (detected by RNA sequencing). All data are presented as means ± SEM, *P < 0.05. (B) CJL altered 5Htt mRNA in the raphe nucleus. This figure shows mRNA levels in raphe nucleus extracts from baseline and CJL treated animals (n = 3 per group), as assayed by three independent qPCR assays, at four different time points (ZT1, ZT7, ZT13, and ZT19). Results are expressed as mean ± SEM. **P < 0.01, ***P < 0.001, two-way ANOVA. Panel (C) represents levels (mean ng g^{– 1} wet weight ± SEM) of dopamine (5-HT) in the hippocampus, hypothalamus, striatum, frontal cortex, accumbens as determined by fluorospectrophotometry. *P < 0.05, **P < 0.01, ***P < 0.001 (n = 304), two-way ANOVA.