TABLE 1.
Psychiatric disorders associated genes were differentially expressed under CJL.
| ZT/Region | Ensemble ID | Gene symbol | Gene name | Fold change |
P-value | Diseases/Disorder | GO term | Related pathways |
| ZT13/NA | ENSMUSG00000 004668 |
Abca13 | ATP binding cassette subfamily A member 13 | 5.78 | 0.005901174 | Shwachman-diamond syndrome 1 and schizophrenia | ATPase and cholesterol transporter activity | CDK-mediated phosphorylation and removal of Cdc6 and innate immune system |
| ZT13/NA | ENSMUSG00000 031654 |
Cbln1 | Cerebellin 1 precursor | 4.32 | 0.001178095 | Depression | Protein homodimerization | |
| ZT13/NA | ENSMUSG00000 022935 |
Grik1 | Glutamate ionotropic receptor kainate type subunit 1 | 1.328 | 0.00669943 | Monosomy 21 and nondisjunction. | Onotropic glutamate receptor activity and | Transmission across chemical synapses and presynaptic function of kainate receptors |
| ZT13/NA | ENSMUSG0000 0085830 |
Grin1os | Glutamate receptor, ionotropic | 0.72 | 0.005276759 | |||
| ZT13/NA | ENSMUSG00000 002771 |
Grin2d | Glutamate ionotropic receptor | 1.40 | 0.020291805 | |||
| ZT13/NA | ENSMUSG00000 023192 |
Grm2 | Glutamate metabotropic receptor 2 | 2.08 | 0.00019965 | Schizophrenia and amphetamine abuse | G-protein coupled receptor activity and glutamate receptor activity | Peptide ligand-binding receptors and signaling by GPCR |
| ZT13/NA | ENSMUSG00000 063239 |
Grm4 | Glutamate metabotropic receptor 4 | 0.73 | 0.024102966 | Epilepsy, idiopathic generalized 10 and schizophrenia | G-protein coupled receptor activity and calcium-dependent protein binding | Peptide ligand-binding receptors and Signaling by GPCR |
| ZT13/NA | Grm8 | Glutamate metabotropic receptor 8 | 1.71 | 0.0000544 | Schizophrenia | GPCRs | G-protein coupled receptor activity and group III metabotropic glutamate receptor activity. | |
| ZT13/NA | ENSMUSG00000 032269 |
Htr3a | 5-Hydroxytryptamine receptor 3A | 1.64 | 0.010275407 | Serotonin syndrome and motion sickness. | Extracellular ligand-gated ion channel activity | Sudden infant death syndrome (SIDS) susceptibility pathways and transport of glucose and other sugars. |
| ZT13/NA | ENSMUSG0000 0028747 |
Htr6 | 5-Hydroxytryptamine receptor 6 | 0.71 | 0.037223485 | Schizophrenia 5 and acute stress disorder | G-protein coupled receptor activity and histamine receptor activity | Monoamine GPCRs and signaling by GPCR |
| ZT13/NA | ENSMUSG00000 059857 |
Ntng1 | Netrin G1 | 1.57 | 0.028761388 | Rett syndrome and schizophrenia | Metabolism of proteins and post-translational modification- synthesis of GPI-anchored proteins | |
| ZT13/NA | ENSMUSG0000 0043811 |
Rtn4r | Reticulon 4 receptor | 1.58 | 0.039552183 | Schizophrenia and acute lymphocytic leukemia | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Guidance Cues and Growth Cone Motility | |
| ZT13/NA | ENSMUSG0000 0032902 |
Slc16a1 | Solute carrier family 16 member 1 | 1.26 | 0.005070062 | Erythrocyte lactate transporter defect and hyperinsulinemic hypoglycemia, familial, 7 | Protein homodimerization activity and monocarboxylic acid transmembrane transporter activity. | Basigin interactions and metabolism |
| ZT13/NA | ENSMUSG0000 0032122 |
Slc37a2 | Solute carrier family 37 member 2 | 0.68 | 0.046427607 | Caffey disease | Transporter activity | |
| ZT13/NA | ENSMUSG0000 0021565 |
Slc6a19 | Solute carrier family 6 member 19 | 3.20 | 0.019754465 | Hartnup disorder and iminoglycinuria | Neurotransmitter: sodium symporter activity and neutral amino acid transmembrane transporter activity | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption |
| ZT13/NA | ENSMUSG0000 0011171 |
Vipr2 | Vasoactive intestinal peptide receptor 2 | 5.55 | 0.006572358 | Schizophrenia 16 and holoprosencephaly 3. | G-protein coupled receptor activity and vasoactive intestinal polypeptide receptor activity | Sudden infant death syndrome (SIDS) susceptibility pathways and signaling by GPCR. |
| ZT1/NA | ENSMUSG00000 004668 |
Abca13 | ATP binding cassette subfamily A member 13 | 5.142 | 0.010892494 | Shwachman-diamond syndrome 1 and schizophrenia | Atpase activity and cholesterol transporter activity | CDK-mediated phosphorylation and removal of Cdc6 and innate immune system |
| ZT1/NA | ENSMUSG00000 024222 |
Fkbp5 | FK506 binding protein 5 | 0.725 | 0.000526409 | Major depressive disorder and post-traumatic stress disorder | Peptidyl-prolyl cis-trans isomerase activity and FK506 binding | Glucocorticoid receptor regulatory network and farnesoid X receptor pathway |
| ZT1/NA | ENSMUSG0000 0029212 |
Gabrb1 | Gamma-aminobutyric acid type A receptor beta1 subunit | 1.27 | 0.04209984 | Epileptic encephalopathy, early infantile, 45 and schizoaffective disorder | Chloride channel activity and GABA-A receptor activity | Akt signaling and neurophysiological process glutamate regulation of dopamine D1A receptor signaling |
| ZT1/NA | ENSMUSG00000 002771 |
Grin2d | Glutamate ionotropic receptor NMDA type subunit 2D | 1.56 | 0.002340667 | Epileptic encephalopathy, early infantile, 46 and undetermined early-onset epileptic encephalopathy | Ionotropic glutamate receptor activity and NMDA glutamate receptor activity | Amyotrophic lateral sclerosis (ALS) and neurophysiological process glutamate regulation of dopamine D1A receptor signaling |
| ZT1/NA | ENSMUSG0000 0028747 |
Htr6 | 5-Hydroxytryptamine receptor 6 | 0.72 | 0.04693987 | Schizophrenia 5 and acute stress disorder | G-protein coupled receptor activity and histamine receptor activity | Monoamine GPCRs and signaling by GPCR |
| ZT1/NA | ENSMUSG00000 006522 |
Itih3 | Inter-alpha-trypsin inhibitor heavy chain 3 | 1.62 | 0.00164351 | Schizophrenia and major depressive disorder | serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. | Response to elevated platelet cytosolic Ca2+ and cell adhesion_cell-matrix glycoconjugates |
| ZT1/NA | ENSMUSG0000 0034755 |
Pcdh11x | Protocadherin 11 X-linked | 1.28 | 0.03337531 | Dyslexia and schizoaffective disorder | calcium ion binding | |
| ZT1/NA | ENSMUSG0000 0031398 |
Plxna3 | Plexin A3 | 1.33 | 0.000730354 | Childhood-onset schizophrenia | Semaphorin receptor activity | Developmental biology |
| ZT1/NA | ENSMUSG0000 0017969 |
Ptgis | Prostaglandin I2 synthase | 0.67 | 0.013953188 | Hypertension, schizophrenia | Adipogenesis and metabolism | |
| ZT1/NA | ENSMUSG0000 0043811 |
Rtn4r | Reticulon 4 receptor | 0.63 | 0.04001688 | Schizophrenia and acute lymphocytic leukemia | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and guidance cues and growth cone motility | |
| ZT1/NA | ENSMUSG0000 0019970 |
Sgk1 | Serum/Glucocorticoid regulated kinase 1 | 0.045 | 9.90934E-18 | Gastric cancer and Liddle syndrome | Transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity | Gene expression and glucocorticoid receptor regulatory network |
| ZT1/NA | ENSMUSG0000 0018459 |
Slc13a3 | Solute carrier family 13 member 3 | 0.73 | 0.008700156 | N-acetylglutamate synthase deficiency | Transporter activityand high-affinity sodium: dicarboxylate symporter activity | Transport of glucose and other sugars, bile salts and organic acids, metal ions, and amine compounds |
| ZT1/NA | ENSMUSG0000 0029843 |
Slc13a4 | Solute carrier family 13 member 4 | 0.24 | 3.88864E-05 | Include transporter activity and sodium: sulfate symporter activity | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |
| ZT1/NA | ENSMUSG0000 0052912 |
Smarca5-ps | SWI/SNF related, matrix associated, | 3.30 | 0.01672786 | |||
| ZT1/NA | ENSMUSG00000 007944 |
Ttc9b | Tetratricopeptide Repeat domain 9B | 0.73 | 0.03778283 | Endogenous depression | Peptidyl-prolyl cis-trans isomerase activity and FK506 binding | |
| ZT13/PFC | ENSMUSG0000 0056629 |
Fkbp2 | FK506 binding protein 5 | 1.31 | 0.006556677 | Major depressive disorder and post-traumatic stress disorder | Peptidyl-prolyl cis-trans isomerase activity and FK506 binding | Glucocorticoid receptor regulatory network and farnesoid X receptor pathway |
| ZT13/PFC | ENSMUSG0000 0024912 |
Fosl1 | FOS like 1, AP-1 transcription factor subunit | 1.31 | 0.029305593 | T-cell leukemia and Pfeiffer syndrome | DNA binding transcription factor activity and RNA polymerase | ERK signaling and integrated breast cancer pathway |
| ZT13/PFC | ENSMUSG0000 0029212 |
Gabrb1 | Gamma-aminobutyric acid type A receptor beta1 subunit | 0.71 | 0.005182001 | Epileptic encephalopathy, early infantile, 45 and schizoaffective disorder | Chloride channel activity and GABA-A receptor activity | Akt signaling and neurophysiological process glutamate regulation of dopamine D1A receptor signaling |
| ZT13/PFC | ENSMUSG0000 0030209 |
Grin2b | Glutamate ionotropic receptor NMDA type subunit 2B | 0.72 | 0.002135375 | e Mental retardation, autosomal dominant 6, with or without seizures and epileptic encephalopathy, early infantile, 27. | Calcium channel activity and ionotropic glutamate receptor activity | Amyotrophic lateral sclerosis (ALS) and neurophysiological process glutamate regulation of dopamine D1A receptor signaling |
| ZT13/PFC | ENSMUSG0000 0034997 |
Htr2a | 5-Hydroxytryptamine receptor 2A | 0.65 | 0.018803838 | Major depressive disorder and obsessive-compulsive disorder | G-protein coupled receptor activity and drug binding | GPCRs, other and sudden infant death syndrome (SIDS) susceptibility pathways |
| ZT13/PFC | ENSMUSG0000 0024525 |
Impa2 | Inositol monophosphatase 2 | 1.46 | 0.022870352 | Bipolar disorder and febrile seizures | Protein homodimerization activity and inositol monophosphate 3-phosphatase activity | Inositol phosphate metabolism and metabolism |
| ZT13/PFC | ENSMUSG0000 0039057 |
Myo16 | Myosin XVI | 1.53 | 0.035595955 | Schizophrenia | Actin binding and actin filament binding | |
| ZT13/PFC | ENSMUSG0000 0026435 |
Slc45a3 | Solute carrier family 45 member 3 | 2.14 | 0.016938843 | Prostate cancer and suppression of tumorigenicity 12 | MicroRNAs in cancer and metabolism | |
| ZT13/PFC | ENSMUSG0000 0031099 |
Smarca1 | SWI/SNF related, matrix associated | 0.69 | 0.023613024 | Rhabdoid tumor predisposition syndrome 1 and Coffin-Siris syndrome 3 | Transcription coactivator activity and RNA polymerase II | Transcription ligand-dependent activation of the ESR1/SP pathway and PEDF induced signaling |
| ZT13/PFC | ENSMUSG0000 0031715 |
Smarca5 | SWI/SNF related, matrix associated | 0.72 | 0.012084672 | Extraskeletal Ewing sarcoma and Williams-Beuren syndrome | Nucleic acid binding and hydrolase activity | Cell cycle, mitotic and activated PKN1 stimulates transcription |
| ZT13/PFC | ENSMUSG0000 0029920 |
Smarcad1 | SWI/SNF-related, matrix-associated | 0.74 | 0.019590473 | Adermatoglyphia and Basan syndrome | Nucleic acid binding and helicase activity | Transcriptional regulatory network in embryonic stem cell and PEDF induced signaling. |
| ZT1/PFC | ENSMUSG0000 0063889 |
Crem | CAMP responsive element modulator | 1.37 | 0.001832659 | Female stress incontinence and type 1 diabetes mellitus 10 | DNA binding transcription factor activity and core promoter | Transcription_CREM signaling in testis and sudden infant death syndrome (SIDS) susceptibility pathways |
| ZT1/PFC | ENSMUSG0000 0024222 |
Fkbp5 | FK506 binding protein 5 | 0.74 | 0.001751921 | Major depressive disorder and post-traumatic stress disorder | Peptidyl-prolyl cis-trans isomerase activity and FK506 binding. | Glucocorticoid receptor regulatory network and farnesoid X receptor pathway |
| ZT1/PFC | ENSMUSG00000 003974 |
Grm3 | Glutamate metabotropic receptor 3 | 1.26 | 0.023136716 | Schizophrenia and bipolar disorder | G-protein coupled receptor activity and glutamate receptor activity | Peptide ligand-binding receptors and signaling by GPCR |
| ZT1/PFC | ENSMUSG00000 002930 |
Ppp1r17 | Protein phosphatase 1 regulatory subunit 17 | 19.35 | 0.006708572 | Hypercholesterolemia, familial | Protein phosphatase inhibitor activity and phosphatase inhibitor activity. | Long-term depression |
| ZT1/PFC | ENSMUSG0000 0032902 |
Slc16a1 | Solute carrier family 16 member 1 | 1.39 | 5.60393E-05 | Erythrocyte lactate transporter defect and hyperinsulinemic hypoglycemia, familial, 7 | Protein homodimerization activity and monocarboxylic acid transmembrane transporter activity | Basigin interactions and metabolism |
| ZT1/PFC | ENSMUSG0000 0020100 |
Slc29a3 | Solute carrier family 29 member 3 | 1.25 | 0.003517058 | Histiocytosis-lymphadenopathy plus syndrome | Nucleoside transmembrane transporter activity | Transport of glucose and other sugars, bile salts and organic acids, metal ion, vitamins and nucleosides. |
| ZT1/PFC | ENSMUSG0000 0019970 |
Sgk1 | Serum/Glucocorticoid regulated kinase 1 | 0.63 | 1.10114E-06 | Gastric cancer | Transferase and protein tyrosine kinase activity | Gene expression |
NA, nucleus accumbens; PFC, prefrontal cortex.