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. 2022 Nov 24;299(1):102745. doi: 10.1016/j.jbc.2022.102745

Figure 2.

Figure 2

Deletion of Nudt7 alters the composition of the acyl-CoA pool in the liver but not the rate of fatty acid oxidation. A, B, D, and E, liver short- and medium-chain acyl-CoA composition in male (A and B) and female (D and E) mice in the fed (A and D) or 24 h–fasted (B and E) states. Data are shown as the mean (bar) of measurements conducted on individual mice (circles) ± SD. Student’s t test, ∗p < 0.05. C and F, rate of fatty acid β-oxidation in primary hepatocytes isolated from fed or 24 h–fasted male (C) and female (F) mice in the presence or absence of etomoxir. Data are shown as the mean (bar) of measurements conducted on individual mice (circles) ± SD. Two-way ANOVA, ## p < 0.01, ### p < 0.001 between mice of the same genotype in the fed versus fasted state. Mitoch., mitochondrial (total – peroxisomal fatty acid oxidation); Perox., peroxisomal (+etomoxir).