Table 2.

Result of genetic correlation estimates with the European population

Metabolite	ρge	SE	Z	p value (ρge < 1)
Citrulline	0.06	0.07	13.99	1.89E-44
Myo-inositol	0.23	0.06	12.19	3.32E-34
1,5-Anhydro-D-sorbitol	0.14	0.07	11.50	1.29E-30
Tryptophan	0.18	0.08	10.85	1.92E-27
Lauric acid	0.26	0.08	9.22	3.02E-20
2-Hydroxyisobutyric acid	0.26	0.08	9.04	1.63E-19
Acetylglycine	0.01	0.12	8.47	2.36E-17
3-Hydroxyisovaleric acid	0.31	0.10	7.19	6.66E-13
Pyruvic acid	−0.42	0.21	6.76	1.42E-11
3-Hydroxybutyric acid	0.04	0.15	6.34	2.24E-10
Aspartic acid	−0.47	0.23	6.28	3.46E-10
Glycine	0.64	0.08	4.39	1.11E-05
Valine	0.44	0.16	3.59	3.31E-04
Uric acid	0.55	0.13	3.40	6.67E-04
Indoxyl sulfate	0.43	0.17	3.28	1.05E-03
Palmitoleic acid	0.50	0.19	2.63	0.01
Tyrosine	0.76	0.20	1.23	0.22
Threonic acid	0.69	0.27	1.17	0.24
Glyceric acid	0.77	0.20	1.14	0.25
Mannose	0.82	0.32	0.57	0.57
Glutamic acid	0.55	0.84	0.53	0.59
Citric acid	0.90	0.20	0.50	0.61
1,6-Anhydroglucose	−0.07	2.38	0.45	0.65
2-Hydroxyisovaleric acid	0.65	2.34	0.15	0.88
Myristic acid	0.26	5.30	0.14	0.89
2-Hydroxybutyric acid	1.00	0.08	0.00	1.00
2-Oxoglutaric acid	1.00	0.10	0.00	1.00
Serinea	1.00	–	–	–
Glutaminea	1.00	–	–	–

Metabolites are listed in bold font if ρ_ge is significantly smaller than 1 (p < 6.5E-04).

^aThe SE of ρ_ge could not be estimated by the jackknife test because all partitions gave the same estimates.