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. 2022 Dec 27;12:22402. doi: 10.1038/s41598-022-26650-9

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Top protein targets identified with spatial profiling: Volcano Plot showing the proteins above a false discovery rate of 30% in peripheral lungs (across all the regions of interest) of smokers without COPD versus GOLD 1–2 COPD (A) and GOLD 1–2 COPD versus GOLD 3–4 COPD (B). The x-axis is the log2 fold change, whereas the y-axis is the log10 of the p-value. In red, the most significantly up-regulated proteins in GOLD 1–2 COPD patients versus smokers (A) and GOLD 3–4 COPD (B).