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. 2022 Dec 13;15:1071719. doi: 10.3389/fnmol.2022.1071719

Figure 1.

Figure 1

Illustration of the developmental dynamic of the OT-system. (A) Schematized patterns of OT produced in the hypothalamus and released in the forebrain (green). OT is first released at birth. (B) Schematized patterns of OTR expression (purple). From E14.5, OTRs progressively appear in several brain regions, with different dynamic patterns of expression. In many areas, OTRs pick between PND14-PND21, followed by either a decline (a) or a stabilization (b); in some areas, a reshaping of OTRs expression occurs at weaning, with a disappearance from some areas and an increase in others (c). The adult pattern of OTR expression is achieved at PND60-90.