FIG. 3.

Cellular immune responses stimulated by the SfbI derivatives. (A) Antigen-specific proliferative responses of spleen and lymph node cells to the specific polypeptide. The obtained results are statistically significant (Student's t test) when values for the H2 and H12 groups are compared with values for the H10 group at P < 0.05 (∗). (B) Effect of B-cell depletion on antigen-specific proliferative responses of spleen cells. Proliferation was assessed after 4 days of culture in the presence of 20 μg of the corresponding antigen/ml by measuring the incorporation of [³H]thymidine (11). Results are expressed as the mean counts per minute (c.p.m.) of triplicate samples; standard deviation is indicated by vertical lines.