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. 2022 Dec 15;8(12):e12381. doi: 10.1016/j.heliyon.2022.e12381

Table 3.

Antimicrobial treatment incidence (ATI) medians in antimicrobial resistance (AMR)-positive and AMR-negative farms.

Number of antimicrobial treatment incidence (ATI)
AMR-positive farms (n = 47) AMR-negative farms (n = 87) p-value
Administration route Intramammary (for dry cow therapy) 20.09 19.17 0.22
Intramammary (for lactating cow) 15.29a 11.37b 0.045
Injection 6.67a 4.79b 0.021
Oral 0.02 0.00 0.23
Intrauterine 0.06 0.00 0.29
Antimicrobial class Tetracyclines 0.93a 0.34b 0.00016
Amphenicol 0 0 0.27
Penicillins 17.30a 14.62b 0.04
Sulfonamides 0.01a 0b 0.018
Macrolides 0.04 0 0.071
Aminoglycosides 12.40 11.29 0.19
Cephalosporins 12.51 9.74 0.051
Trimetoprim 0 0 0.33
Quinolones 0.12 0.05 0.065
Total 45.17a 38.4b 0.023

AMR-positive farms: farms in which methicillin-resistant staphylococci (MRS) or extended-spectrum β-lactamase (ESBL)-producing coliforms (E. coli and Klebsiella spp.) were detected in at least one mastitic milk sample.

AMR-negative farms: farms in which neither MRS nor ESBL-producing coliforms were detected in the mastitic milk samples.

a - b: significant difference between AMR-positive and AMR-negative farms (p < 0.05, Wilcoxon rank-sum test).