Table 1.

Performance evaluation of the jointly optimized HTVS pipeline based on 5-fold cross-validation (target RP threshold at the last stage set to 2.5 V)

$\alpha$	Detected materials	Total cost (seconds)	Effective cost (seconds)	Sensitivity	Specificity	F1 score	Accuracy
0.25	40.4	3,450,440	85,407	0.7769	1	0.8714	0.8619
0.5	47.8	4,365,990	91,339	0.9192	1	0.9574	0.95
0.75	49.8	4,645,890	93,291	0.9577	1	0.9782	0.9738

As the weight parameter $\alpha$, which determines the balance between the throughput and computational efficiency, increased from 0.25 to 0.75, all the throughput-related performance metrics tended to improve at the cost of higher computational cost (i.e., increased total cost and effective cost). Overall, the optimized HTVS pipeline struck a good balance between throughput and computational efficiency.