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. Author manuscript; available in PMC: 2022 Dec 27.
Published in final edited form as: Br J Pharmacol. 2021 Aug 7;178(20):4119–4136. doi: 10.1111/bph.15602

Figure 1.

Figure 1.

Effects of ACh. Representative traces showing concentration-dependent effects of the NO-producing agonist ACh on the spontaneous contractions of WT (A) and Kir6.1−/− (B) mouse popliteal lymphatics held at a constant pressure of 3 cmH2O. Normalized amplitude (C), normalized frequency (D) and change in EDD (E) plotted as a function of NONOate concentration, from 10 nM to 3 μM. Filled circles indicate WT vessels (n=25) and open circles indicate Kir6.1−/− vessels (n=9). All data are means ± SEM. There were no significant differences between WT and Kir6.1−/− data points at any NONOate concentration. * Significant difference in WT data from control (absence of ACh). † Significant difference in Kir6.1−/− data from control.