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. Author manuscript; available in PMC: 2022 Dec 27.
Published in final edited form as: Br J Pharmacol. 2021 Aug 7;178(20):4119–4136. doi: 10.1111/bph.15602

Figure 4.

Figure 4.

Effect of 10 μM glibenclamide (GLIB) on NONOate-induced responses in WT vessels. Raw traces showing NONOate-induced responses in the absence (A) or presence of 10 μM GLIB (B). Comparisons of contraction amplitude (C) or frequency (D) before (“Krebs”) and after treatment of 10 μM GLIB alone. * Significant using paired Student’s t-test. Lymphatic contraction parameters were normalized to their respective values prior to GLIB treatment (E-G). Comparisons of NONOate-induced effects on normalized amplitude (E), normalized frequency (F) and change in EDD (G) in the absence (n=12; black closed circles) or presence of 10 μM GLIB (n=11; red closed squares). All data are means ± SEM. * Significant difference in data from control for NONOate in the absence of GLIB. # Significant difference in data from control for NONOate in the presence of GLIB. ¥ Significant difference in data between NONOate alone and NONOate + GLIB.