Table 1.
Summary of IC50 values
| Drug | WT | Kir6.1−/− | |
|---|---|---|---|
| ACh | FREQ | 2.70 × 10−8 M | 2.14 × 10−8 M |
| EDD | 3.14 × 10−8 M | 1.22 × 10−8 M | |
| NONOate | FREQ | 8.63 × 10−8 M | 9.51 − 10−8 M |
| EDD | 9.50 × 10−8 M | 1.85 × 10−7 M | |
| GLIB+NONOate | FREQ | 7.27 × 10−8 M | - |
| EDD | 1.45 × 10−7 M | - | |
| ODQ+NONOate | FREQ | # | # |
| EDD | # | # | |
| Rp-8-Br-PET-GMPS+NONOate | FREQ | 1.36 × 10−6 M | # |
| EDD | 1.12 × 10−6 M | # | |
| NS11021 | FREQ | 2.53 × 10−6 M | 1.08 × 10−6 M |
| EDD | # | # | |
| IbTX+NONOate | FREQ | # | - |
| EDD | # | - | |
| Penitrem A+NONOate | FREQ | # | - |
| EDD | # | - | |
| IbTX+ACh | FREQ | 1.25 × 10−7 M | - |
| EDD | 1.53 × 10−8 M | - | |
| Penitrem A+ACh | FREQ | 2.14 × 10−7 M | - |
| EDD | 2.05 × 10−8 M | - | |
| Apamin+NONOate | FREQ | 2.69 × 10−7 M | - |
| EDD | 2.42 × 10−7 M | - |
#
Could not be fit to the Hill equation.