Table S11.
Percentage of grades 1/2 and 3/4 adverse events and number of events per year
| Adverse event | GRADE 1/2 | GRADE 3/4 | ||||||
|---|---|---|---|---|---|---|---|---|
| Diagnosed patients | No. of events | Non-diagnosed patients | No. of events | Diagnosed patients | No. of events | Non-diagnosed patients | No. of events | |
| Nausea and vomiting | 20.39% | 1 | 89.35% | 3.5 | 0.66% | 0.5 | 4.73% | 0.5 |
| Constipation/diarrhea | 11.84% | 2 | 12.43% | 4.5 | 0.00% | 0 | 0.59% | 1 |
| Fatigue | 7.24% | 1 | 59.17% | 6 | 0.00% | 0 | 3.55% | 2 |
| Peripheral edema | - | - | - | - | 0.00% | 0 | 0.59% | 1 |
| Anemia | 15.13% | 1 | 23.08% | 4 | 4.61% | 1 | 8.88% | 1 |
| Neutropenia | 0.00% | 0 | 14.79% | 1 | 0.00% | 0 | 15.38% | 1 |
| Increased Alanine transaminase (ALT) | - | - | - | - | 4.61% | 1 | 1.18% | 1 |
| Increased Aspartate transaminase (AST) | - | - | - | - | 5.26% | 1 | 1.18% | 1 |
| Increased bilirubin | - | - | - | - | 1.97% | 1 | 0.00% | 0 |
| Leukopenia | 0.00% | 0 | 10.06% | 1 | 0.00% | 0 | 5.33% | 1 |
| Thrombocytopenia | 0.00% | 0 | 11.83% | 1 | 0.00% | 0 | 6.51% | 1 |