Table 2. The detailed search queries per database.
Ab: abstract; Ti: title; Kw: keywords; Py: publication year; MP: Multi-purpose; TS: topic
| S.N. | Embase | Results | Web of Science | Results | Ovid MEDLINE | Results |
| 1 | (“Genetic engineering”/exp) OR (“genetic manipulation”/exp) | 164,848 | TS = ("gen* edit*" OR "gen* engineer*" OR "gen* manipulation") | 67,710 | Exp Genetic Engineering/ | 223,931 |
| 2 | (“Gen* edit*”: ab, ti, kw) OR (“gen* engineer*”: ab, ti, kw) OR (“gen* manipulation”: ab, ti, kw) | 68,495 | TS = ("clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen) | 35,685 | ("Gen* edit*" OR "gen* engineer*" OR "gen* manipulation"). Mp. | 75,226 |
| 3 | (“Clustered regularly interspaced short palindromic repeat”/exp) OR (“crispr cas system”/exp) | 46,599 | TS = (ethic* OR moral* OR bioethic*) | 425,596 | Exp Clustered Regularly Interspaced Short Palindromic Repeats/ | 4,975 |
| 4 | (“Clustered regularly interspaced short palindromic repeats”: ab, ti, kw) OR (crispr*: ab, ti, kw) OR (meganuclease*: ab, ti, kw) OR (“zinc finger nuclease”: ab, ti, kw) OR (“transcription activator like effector nuclease*”: ab, ti, kw) OR (talen: ab, ti, kw) | 46,492 | (TS = {"gen* edit*" OR "gen* engineer*" OR "gen* manipulation"}) OR (TS = {"clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen}) | 90,734 | Exp CRISPR-Cas Systems/ | 15,161 |
| 5 | (“Ethics”/exp) OR (“morality”/exp) | 363,185 | ({TS = ("gen* edit*" or "gen* engineer*" or "gen* manipulation")} OR {TS = ("clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen)}) AND (TS = {ethic* OR moral* OR bioethic*}) | 1,635 | Exp Ethics/ | 153,766 |
| 6 | (Ethic*: ab, ti, kw) OR (moral*: ab, ti, kw) OR (bioethic*: ab, ti, kw) | 265,004 | ({TS = ("gen* edit*" or "gen* engineer*" or "gen* manipulation")} OR {TS = ("clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen)}) AND (TS = {ethic* OR moral* OR bioethic*}) from 2013-2022 | 1,157 | Exp Morals/ | 179,597 |
| 7 | (“Animal”/exp OR “animal experiment”/exp OR “animal model”/exp OR “invertebrate”/exp OR “animal tissue”/exp OR “animal cell”/exp OR “nonhuman”/exp) NOT (“human”/exp OR “normal human”/exp) | 7,639,438 | - | - | (Ethic* OR moral* OR bioethic*). Mp. | 273,195 |
| 8 | (“Genetic engineering”/exp OR “genetic manipulation”/exp) OR (“gen* edit*”: ab, ti, kw OR “gen* engineer*”: ab, ti, kw OR “gen* manipulation”: ab, ti, kw) OR (“clustered regularly interspaced short palindromic repeat”/exp OR “crispr cas system”/exp) OR (“clustered regularly interspaced short palindromic repeats”: ab, ti, kw OR crispr*: ab, ti, kw OR meganuclease*: ab, ti, kw OR “zinc finger nuclease”: ab, ti, kw OR “transcription activator like effector nuclease*”: ab, ti, kw OR talen: ab, ti, kw) | 215,899 | - | - | ("Clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen). Mp. | 36,007 |
| 9 | (“Ethics”/exp OR “morality”/exp) OR (ethic*: ab, ti, kw OR moral*: ab, ti, kw OR bioethic*: ab, ti, kw) | 482,370 | - | - | (Exp Genetic Engineering/) OR ({"Gen* edit*" OR "gen* engineer*" OR "gen* manipulation"}. Mp.) OR (Exp Clustered Regularly Interspaced Short Palindromic Repeats/) OR (Exp CRISPR-Cas Systems/) OR ({"Clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen}. Mp.) | 278,768 |
| 10 | ({“Genetic engineering”/exp OR “genetic manipulation”/exp} OR {“gen* edit*”: ab, ti, kw OR “gen* engineer*”: ab, ti, kw OR “gen* manipulation”: ab, ti, kw} OR {“clustered regularly interspaced short palindromic repeat”/exp OR “crispr cas system”/exp} OR {“clustered regularly interspaced short palindromic repeats”: ab, ti, kw OR crispr*: ab, ti, kw OR meganuclease*: ab, ti, kw OR “zinc finger nuclease”: ab, ti, kw OR “transcription activator like effector nuclease*”: ab, ti, kw OR talen: ab, ti, kw}) AND ({“ethics”/exp OR “morality”/exp} OR {ethic*: ab, ti, kw OR moral*: ab, ti, kw OR bioethic*: ab, ti, kw}) | 4,233 | - | - | (Exp Ethics/) OR (Exp Morals/) OR ({Ethic* OR moral* OR bioethic*}. Mp.) | 320,345 |
| 11 | ({“Genetic engineering”/exp OR “genetic manipulation”/exp} OR {“gen* edit*”: ab, ti, kw OR “gen* engineer*”: ab, ti, kw OR “gen* manipulation”: ab, ti, kw} OR {“clustered regularly interspaced short palindromic repeat”/exp OR “crispr cas system”/exp} OR {“clustered regularly interspaced short palindromic repeats”: ab, ti, kw OR crispr*: ab, ti, kw OR meganuclease*: ab, ti, kw OR “zinc finger nuclease”: ab, ti, kw OR “transcription activator like effector nuclease*”: ab, ti, kw OR talen: ab, ti, kw}) AND ({“ethics”/exp OR “morality”/exp} OR {ethic*: ab, ti, kw OR moral*: ab, ti, kw OR bioethic*: ab, ti, kw}) AND [2013-2022]/py | 1,897 | - | - | ({Exp Genetic Engineering/} OR {"Gen* edit*" OR "gen* engineer*" OR "gen* manipulation"}. Mp.) OR (Exp Clustered Regularly Interspaced Short Palindromic Repeats/) OR (Exp CRISPR-Cas Systems/) OR ({"Clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen}. Mp.) AND ({Exp Ethics/} OR (Exp Morals/) OR ({Ethic* OR moral* OR bioethic*}. Mp.}) | 4,791 |
| 12 | ({“genetic engineering”/exp OR “genetic manipulation”/exp} OR (“gen* edit*”: ab, ti, kw OR “gen* engineer*”: ab, ti, kw OR “gen* manipulation”: ab, ti, kw) OR (“clustered regularly interspaced short palindromic repeat”/exp OR “crispr cas system”/exp) OR (“clustered regularly interspaced short palindromic repeats”: ab, ti, kw OR crispr*: ab, ti, kw OR meganuclease*: ab, ti, kw OR “zinc finger nuclease”: ab, ti, kw OR “transcription activator like effector nuclease*”: ab, ti, kw OR talen: ab, ti, kw)} AND {(“ethics”/exp OR “morality”/exp) OR (ethic*: ab, ti, kw OR moral*: ab, ti, kw OR bioethic*: ab, ti, kw}) AND ([2013-2022]/py) NOT ({“animal”/exp OR “animal experiment”/exp OR “animal model”/exp OR “invertebrate”/exp OR “animal tissue”/exp OR “animal cell”/exp OR “nonhuman”/exp) NOT (“human”/exp OR “normal human”/exp}) | 1,774 | - | - | Limit ({(Exp Genetic Engineering/) OR {("Gen* edit*" OR "gen* engineer*" OR "gen* manipulation"). Mp.} OR (Exp Clustered Regularly Interspaced Short Palindromic Repeats/) OR (Exp CRISPR-Cas Systems/) OR {("Clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen). Mp.}} AND {(Exp Ethics/) OR (Exp Morals/) OR {(Ethic* OR moral* OR bioethic*). Mp.}}) to yr = “2013-2022” | 1,580 |
| 13 | - | - | - | - | (Limit ({(Exp Genetic Engineering/) OR {("Gen* edit*" OR "gen* engineer*" OR "gen* manipulation"). Mp.} OR (Exp Clustered Regularly Interspaced Short Palindromic Repeats/) OR (Exp CRISPR-Cas Systems/) OR {("Clustered regularly interspaced short palindromic repeats" OR crispr* OR meganuclease* OR "zinc finger nuclease" OR "transcription activator like effector nuclease*" OR talen). Mp.}} AND {(Exp Ethics/) OR (Exp Morals/) OR {(Ethic* OR moral* OR bioethic*). Mp.}}) to (yr = “2013-2022”) NOT (Animals/ not {Animals/ and Humans/}) | 1,514 |