Table 2.
Liver function and volume changes in patients with colorectal liver metastases undergoing hepatectomy during perioperative period
| Variable | Pre-operative | POD7 | POD28 | p-value |
|---|---|---|---|---|
| ICG-R15 (%) | 7.9 (0.4–14.7) | 11.1 (1.2–23.3) | 8.3 (3.9–21.0) | 0.196 |
| Hepatobiliary scintigraphy | ||||
| FLR-F (%/min/m2 ) | 3.1 (2.3–4.7) | 5.5 (4.1–7.9) | 6.6 (5.2–7.7) | < 0.001 |
| sFLR-F (%) | 36 (25–48) | 65 (44–93) | 75 (56–94) | < 0.001 |
| Gadoxetic acid-enhanced MRI | ||||
| LMR | 2.04 (1.50–2.49) | 1.78 (1.43–2.30) | 2.04 (1.88–2.43) | 0.069 |
| LSR | 1.95 (1.26–2.67) | 1.77 (1.29–2.54) | 2.04 (1.77–2.56) | 0.025 |
| HUI | 496 (202–870) | 763 (373–1665) | 1343 (921–1525) | 0.001 |
| Liver volume | ||||
| FLR-V (ml) | 546 (377–772) | 1039 (744–1307) | 1194 (971–1404) | < 0.001 |
| sFLR-V (%) | 38 (29–53) | 69 (55–81) | 79 (66–90) | < 0.001 |
| Interval POD 1–7 | Interval POD 1–28 | |||
| Kinetic growth rate | ||||
| KGR-F (%/week) | - | 31 (5–45) | 10 (6–13) | < 0.001, b |
| KGR-V (%/week) | - | 30 (19–47) | 9 (6–13) | 0.003, b |
FLR, future liver remnant; FLR-F, future liver remnant function represented by corrected mebrofenin uptake rate; FLR-V, future liver remnant volume; HUI, hepatic uptake index; ICG-R15, indocyanine green retention test at 15 min; KGR-F, kinetic growth rate in function; KGR-V, kinetic growth rate in volume; LMR, liver-to-muscle ratio; LSR, liver-to-spleen ratio; POD, post-operative day; sFLR-F, standardized FLR-F; sFLR-V, standardized FLR-V.
Note: Data are expressed as median with range. p values are calculated by repeated measures analysis of variance.
a
statistically significant
b
compared by the Mann Whitney U test