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. 2022 Dec 27;11:57. doi: 10.1186/s40035-022-00333-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — FUS-mediated BBB opening significantly increased the delivery of Adu in the brain. a A scheme of the FUS system set up for BBB opening in mice. b A schematic diagram for unilateral (upper panel) and bilateral (lower panel) FUS sonication. c Pre- and post-gadolinium T1-weighted images: FUS-mediated BBB opening was confirmed with MRI. d FUS was treated unilaterally to the brains of experimental animals. A representative image of Western blotting with an antibody against human IgG after Adu injection and unilateral FUS treatment. e Representative confocal images (20x) of human IgG (Aducanumab), Aβ stained with 6E10 antibody and DAPI in the dentate gyrus of the hippocampus. f A bar graph showing the levels of Adu assessed with human IgG antibody in the hippocampus. Data are presented as mean ± SEM. Statistical analyses were performed using one-way ANOVA, followed by Tukey’s post hoc analysis. (****P < 0.0001, ***P < 0.001, n = 5 mice for each group)