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. 2022 Dec 27;11:57. doi: 10.1186/s40035-022-00333-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Treatment of FUS and Adu altered gene expression profiles in the hippocampus. a Left figure is a volcano plot. The x-axis represents the log₂ conversion of the fold change (FC) values, and the y-axis represents the corrected significance level after base log₁₀ conversion (q value). Green dots in the volcano plot and right graph indicate all DEGs that were found to differ significantly (q value < 0.05). The black bar in the right graph represents the number of genes with an absolute value of log₂ FC greater than 0.7, and the gray bar represents the number of genes with an absolute value of log₂ FC less than 0.7. b Canonical pathway analysis. Activated canonical pathway (blue bar) and inhibited canonical pathway (red bar) were identified (Z score > 1 or < − 1). c A heatmap of upstream regulators (Z score > 1 or < − 1). d A gene interaction network map (upper) and related DEGs’ log₂ FC values (lower). e A heatmap of canonical pathways via comparison analysis (left) and four selected canonical pathways, including related molecules