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. 2022 Dec 27;24:26. doi: 10.1186/s12575-022-00189-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — The regulatory relationship between the hub genes, cAMP signaling, and salivary secretion. A Construction of regulatory networks between upregulated hub genes and DEGs of cAMP signaling and salivary secretion. B Construction of regulatory networks between downregulated hub genes and DEGs of cAMP signaling and salivary secretion. The red triangle represents the upregulation of common DEGs, the green triangle represents the downregulation of common DEGs, the red circle represents the upregulation of hub genes, the green circle represents the downregulation of hub genes, and the blue circle represents the pathway