Table 2.

Odds Ratios and 95% Confidence Intervals for Body Composition Variables and Objective Response to ICB as defined by RECIST criteria, n=192

	CR n=8 (4%)	PR n=44 (23%)	SD ≥ 6 mo n=27 (14%)	SD <6 mo n=45 (23%)	PD n=68 (35%)	OR* (95% CI)	P-value
BMI
Obese + Overweight (BMI≥25 kg/m2)	6 (4%)	31 (22%)	21 (15%)	30 (21%)	52 (37%)	1.04 (0.55, 2.01)	0.90
Normal weight (BMI<25 kg/m2)	2 (4%)	13 (25%)	6 (12%)	15 (29%)	16 (31%)	1.0 (reference)
SMI
High SMI	4 (4%)	23 (25%)	11 (12%)	23 (25%)	31 (34%)	1.0 (reference)	0.97
Low SMI	4 (4%)	21 (21%)	16 (16%)	22 (22%)	37 (37%)	0.99 (0.56, 1.76)
VATI
High VATI	5 (5%)	19 (19%)	17 (17%)	25 (25%)	33 (33%)	0.97 (0.55, 1.74)	0.94
Low VATI	3 (3%)	25 (27%)	10 (11%)	20 (22%)	35 (38%)	1.0 (reference)
SATI
Low SATI	2 (2%)	23 (23%)	12 (12%)	26 (27%)	35 (36%)	0.75 (0.42, 1.34)	0.33
High SATI	6 (6%)	21 (22%)	15 (16%)	19 (20%)	33 (35%)	1.0 (reference)

Abbreviations: ICB=Immune Checkpoint Blockade; OR=Odds Ratio; CI= Confidence Intervals; RECIST=Response Evaluation Criteria in Solid Tumors; CR=Complete Response; PR=Partial Response; SD=Stable Disease; PD=Progressive Disease; BMI=Body Mass Index; SMI=Skeletal Muscle Index; VATI=Visceral Adipose Tissue Index; SATI= Subcutaneous Adipose Tissue Index

Row percentages are shown.

^*OR compares CR+PR+SD for > 6 months vs. PD and SD <6 months