Fig. 1.

Effects of GP17 on infarct volume, neurological deficit scores and neuronal pathological changes in MCAO/R injury rats. A Chemical structure of GP-17. B and C Neurological deficit scores in all groups (n=10). D Representative images of TTC-stained brain sections from the Sham-operated or GP17-treated animals collected 24 h after infarction; Red tissue is healthy; white tissue is infarcted. E Quantitative analysis of the infarct volume (n=3–5). F Rat weight in all groups (n=6–10). G Representative images (X400) of H/E staining performed in cortex and hippocampus CA1, CA3 regions from ischemic brains, scale bar =100 μm. H and I, Quantitative analysis of pathological grading scores (n=3–4). Statistical comparisons were performed as follows: one-way ANOVA with Dunnett’s multiple comparisons test for (B, C, E and F); Wilcoxon test for (H and I); ^*P<0.05, ^**P<0.01 versus MCAO/R group; ^#P<0.05, ^##P<0.01 versus Sham group