Table 2.
Tumor and lymphoid organ metrics for the pre-therapy scan (t0), post-therapy scan (t1) and rates of change (Δ)
| t0 | t1 | Δ(t0) | Δ(t1) | |
|---|---|---|---|---|
| Tumor | ||||
| MTV, ml | 39.5 (7.9–284.4) | 30.6 (4.9–224.6) | 1.35 (0.49–2.31) | |
| TLG, ml | 308.9 (19.1–1802.1) | 132.8 (15.2–2085.9) | 1.35 (0.29–3.73) | |
| SUVmean | 7.6 (5.0–9.7) | 6.2 (3.4–10.8) | 0.94 (0.61–1.13) | 1.08 (0.81–1.36) |
| SUVmax | 16.9 (9.9–24.6) | 11.6 (6.9–25.9) | 0.76 (0.53–1.42) | 1.02 (0.67–1.53) |
| V, ml | 27.2 (1.5–54.2) | 12.9 (2.7–129.5) | 1.37 (0.71–2.09) | 1.37 (0.71–2.09) |
| Vtotal, ml | 34.7 (4.0–219.9) | 17.6 (3.4–202.7) | 1.60 (0.78–2.39) | |
| ADCmean, × 10-3 mm2/s | 0.89 (0.66–1.10) | 1.01 (0.71–1.34) | 1.17 (1.03–1.64) | 0.92 (0.80–1.16) |
| Bone marrow | ||||
| SUVmean | 1.8 (1.2–2.4) | 1.3 (0.9–1.9) | 0.79 (0.66–0.86) | |
| FF, % | 81 (73–88) | 82 (79–86) | 1.01 (0.99–1.09) | |
| ADCmean, × 10-3 mm2/s | 0.49 (0.44–0.59) | 0.51 (0.40–0.57) | 1.01 (0.79–1.09) | |
| Spleen | ||||
| SUVmean | 1.9 (1.7–2.2) | 1.8 (1.5–2.1) | 0.93 (0.79–0.99) | |
| V, ml | 136.9 (83.1–273.7) | 155.8 (93.1–261.7) | 1.09 (0.99–1.21) | |
| ADCmean, × 10-3 mm2/s | 1.04 (0.82–1.15) | 0.91 (0.68–0.96) | 0.91 (0.76–1.10) | |
Median values with the IQR in parentheses. Δ(t0) corresponds to the rate of change with pre-therapy target lesion selection, while Δ(t1) corresponds to the rate of change with post-therapy target lesion selection