Table 3.
Univariate analysis for PFS and OS
| Pre-therapy | Δ | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PFS | OS | PFS | OS | ||||||||||
| Variable | HR (95% CI) | p-value | FDR | HR (95% CI) | p-value | FDR | HR (95% CI) | p-value | FDR | HR (95% CI) | p-value | FDR | |
| Basic | Age | 1.02 (0.95–1.11) | 0.55 | 0.69 | 1.05 (0.97–1.14) | 0.21 | 0.37 | – | – | – | – | – | – |
| BMI | 0.89 (0.79–1.00) | 0.051 | 0.15 | 0.96 (0.88–1.04) | 0.29 | 0.41 | – | – | – | – | – | – | |
| Gender | 1.12 (0.37–3.34) | 0.84 | 0.84 | 1.14 (0.36–3.62) | 0.83 | 0.83 | – | – | – | – | – | – | |
| Lugano | 2 groups | – | – | – | – | 1.79 (0.60–5.39) | 0.29 | 0.51 | 1.19 (0.37–3.76) | 0.77 | 0.92 | ||
| Tumor | Lesions | 1.01 (0.97–1.05) | 0.622 | 0.70 | 0.97 (0.92–1.03) | 0.27 | 0.41 | 1.44 (0.66–3.16) | 0.36 | 0.57 | 1.69 (0.78–3.69) | 0.18 | 0.37 |
| MTV | 1.48 (1.08–2.01) | 0.00079 | 0.012 | 1.27 (0.98–1.65) | 0.046 | 0.19 | 1.71 (1.11–2.64) | 0.0093 | 0.070 | 1.40 (0.98–2.00) | 0.058 | 0.19 | |
| TLG | 1.02 (1.00–1.04) | 0.0054 | 0.023 | 1.03 (1.01–1.05) | 0.0014 | 0.024 | 1.46 (1.03–2.05) | 0.022 | 0.089 | 1.30 (0.97–1.75) | 0.071 | 0.19 | |
| Vtotal | 1.63 (1.14–2.34) | 0.0015 | 0.012 | 1.34 (0.96–1.88) | 0.075 | 0.19 | 1.95 (1.06–3.58) | 0.024 | 0.089 | 1.74 (1.03–2.92) | 0.031 | 0.19 | |
| SUVmean, t0 | 1.06 (0.94–1.18) | 0.35 | 0.54 | 1.10 (0.96–1.25) | 0.18 | 0.37 | 1.34 (0.45–4.02) | 0.60 | 0.75 | 1.06 (0.32–3.56) | 0.93 | 0.98 | |
| SUVmax, t0 | 1.03 (0.99–1.06) | 0.15 | 0.32 | 1.04 (0.99–1.08) | 0.077 | 0.19 | 1.84 (0.87–3.90) | 0.10 | 0.23 | 1.05 (0.61–1.83) | 0.86 | 0.96 | |
| V, t0 | 1.61 (1.06–2.43) | 0.013 | 0.043 | 1.90 (1.14–3.19) | 0.0043 | 0.037 | 1.63 (0.96–2.76) | 0.062 | 0.20 | 1.45 (0.94–2.25) | 0.086 | 0.20 | |
| ADCmean, t0 | 0.82 (0.14–4.93) | 0.83 | 0.84 | 1.28 (0.29–5.69) | 0.75 | 0.79 | 0.69 (0.16–3.09) | 0.63 | 0.75 | 0.44 (0.096–2.03) | 0.29 | 0.46 | |
| SUVmean, t1 | – | – | – | – | – | 2.12 (0.73–6.19) | 0.17 | 0.31 | 1.91 (0.58–6.28) | 0.28 | 0.46 | ||
| SUVmax, t1 | – | – | – | – | – | 2.34 (1.17–4.71) | 0.011 | 0.070 | 1.21 (0.75–1.96) | 0.43 | 0.58 | ||
| V, t1 | – | – | – | – | – | 1.07 (0.98–1.16) | 0.11 | 0.23 | 1.09 (0.99–1.19) | 0.038 | 0.19 | ||
| ADCmean, t1 | – | – | – | – | – | 0.083 (0.012–0.57) | 0.0091 | 0.070 | 0.099 (0.0099–0.99) | 0.040 | 0.19 | ||
| Bone marrow | SUVmean | 0.24 (0.083–0.69) | 0.0044 | 0.023 | 0.28 (0.094–0.83) | 0.014 | 0.080 | 10.51 (0.77–143.40) | 0.073 | 0.20 | 19.74 (0.77–504.00) | 0.066 | 0.19 |
| FFmean | 1.01 (0.97–1.06) | 0.51 | 0.69 | 1.06 (0.99–1.14) | 0.066 | 0.79 | 0.053 (0–95.21) | 0.44 | 0.60 | 0 (0–1.97) | 0.058 | 0.19 | |
| ADCmean | 3.54 (0.047–264.10) | 0.57 | 0.69 | 0.44 (0.0051–37.28) | 0.71 | 0.19 | 1.42 (0.070–28.76) | 0.82 | 0.86 | 3.04 (0.14–65.09) | 0.48 | 0.60 | |
| Spleen | SUVmean | 0.24 (0.051–1.12) | 0.066 | 0.16 | 0.65 (0.17–2.45) | 0.52 | 0.68 | 1.42 (0.028–71.07) | 0.86 | 0.86 | 7.32 (0.12–462.50) | 0.35 | 0.50 |
| V | 0.76 (0.45–1.29) | 0.31 | 0.52 | 1.11 (0.71–1.72) | 0.65 | 0.79 | 0.25 (0.0083–7.49) | 0.42 | 0.60 | 0.15 (0.0061–3.51) | 0.23 | 0.44 | |
| ADCmean | 0.27 (0.023–3.14) | 0.29 | 0.52 | 0.26 (0.029–2.27) | 0.22 | 0.37 | 1.76 (0.092–33.37) | 0.71 | 0.79 | 0.97 (0.049–19.05) | 0.98 | 0.98 | |
Statistically significant results are depicted in bold (p < 0.05, FDR < 0.05). For rate of change (Δ) in tumor SUVmean, SUVmax, V and ADCmean, the target lesion was selected at t0 and at t1. Hazard ratios (HRs) for volume metrics (MTV, TLG, V and Vtotal) presented in dl unit change