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. Author manuscript; available in PMC: 2022 Dec 27.
Published in final edited form as: Nat Neurosci. 2021 Aug 16;24(10):1356–1366. doi: 10.1038/s41593-021-00902-9

Figure 3: Approaches to extend multiphoton holographic optogenetics.

Figure 3:

a) Two-photon mesoscopes could be outfitted with holographic pathways to obtain high fidelity optogenetic control over very large brain volumes. b) GRIN lenses can be used to relay holographic patterns from conventional holographic systems into deep brain circuits. c) Removal of overlying tissue can allow direct access to deeper structures, such as the hippocampus. d) The two-photon microscopes could be directly coupled to an optic fiber or miniatured and head-mounted.