TABLE 4.
Putative function transfer
| pfamid | pfam_description | PDB hit's family | PDB‐id | Z | %ide | Shared motif |
|---|---|---|---|---|---|---|
| PF00674 | DUP family | Myb‐like DNA‐binding domain | 2m3aA | 5.3 | 18 | Conserved Pro, Trp |
| PF04755 | Plastid lipid associated protein and fibrillins | PF00061 Lipocalin/cytosolic fatty‐acid binding protein | 2wq9A | 9.5 | 11 | Conserved Trp |
| PF04937 | DUF659 Protein of unknown function | Transposase | 2bw3A | 7.9 | 13 | Conserved Trp, Asp, Cys |
| PF05212 | Protein of unknown function (DUF707) | PF00535 glycosyltransferase family 2 | 6h2nB | 12.7 | 7 | Conserved DxD contact substrate |
| PF05444 | Protein of unknown function (DUF753) | LY6/PLAUR domain | 6ionA | 5.4 | 23 | Five conserved disulfide bridges |
| PF05912 | Caenorhabditis elegans protein of unknown function (DUF870) | PF01060 Transthyretin‐like family (CL0287) | 3uafA | 9.5 | 17 | C, HxC form conserved disulfide bridge |
| PF07505 | Protein of unknown function (DUF5131) |
Spore photoproduct lyase |
4rh1A | 14.1 | 11 |
Three conserved Cys and Asp |
| PF07712 | Stress up‐regulated Nod 19 | Pf01082 & PF03712 Copper type II ascorbate‐dependent monooxygenase, N‐terminal & C‐terminal domains (CL0612) | 6alaA | 17.1 | 11 | Conserved HH, HxH, M contact cofactor |
| PF08795 | Putative papain‐like cysteine peptidase (DUF1796) | PF08942 Domain of unknown function (DUF1919) | 2g6tA | 7.3 | 11 | Conserved catalytic dyad Cys30/Cys119, His90/His192 |
| PF09725 | Folate‐sensitive fragile site protein Fra10Ac1 | N‐terminal zinc finger domain of transcription repressor Val1 | 5yugE | 2.7 | 16 | Conserved CCCC zinc finger |
| PF09887 | Uncharacterized protein conserved in archaea (DUF2114) | PF03702 Anhydro‐N‐acetylmuramic acid kinase (CL0108) | 4bgbB | 18.5 | 13 | GN, G, D ‐ Asp233/Asp165 contact substrate |
| PF09892 | Uncharacterized protein conserved in archaea (DUF2119) | PF04952 Succinylglutamate desuccinylase/Aspartoacylase family | 3cdxF | 10.6 | 13 | Conserved calcium binding residues GxHGxE, H, E |
| PF09909 | Uncharacterized protein conserved in bacteria (DUF2138) | Fusion of (i) the treponema porin (t‐por) family, and (ii) PF14032 PknH‐like extracellular domain (CL0619) |
3k8iA 4esqA |
7.9 6.2 |
9 7 |
Structural modeling suggests it is a fusion of porin and extracellular sensor domain |
| PF10118 | Predicted metal‐dependent hydrolase | PF00268 ribonucleotide reductase, small chain | 1w69A | 14.0 | 13 | Conserved E, H, E, H in active site |
| PF10170 | Cysteine‐rich domain | PF02318 FYVE‐like zinc finger (CL0390) | 2cjsC | 4.4 | 23 | Two CCCC zinc fingers |
| PF10223 | Uncharacterized conserved protein (DUF2181) | PF03009 phosphodiesterase (CL0384) | 4oecB | 16.3 | 19 | Conserved H, ExD, H bind Mg ion |
| PF10561 | C2orf69 | PF00756 Putative esterase | 6gi0A | 6.0 | 10 | Conserved GxSxGG motif in catalytic site (Perraud et al., 2018) |
| PF10936 | Protein of unknown function (DUF2617) | PF01536 Adenosylmethionine decarboxylase | 1jl0A | 8.1 | 12 | Conserved catalytic His (Ekstrom et al., 2001) |
| PF10974 | Protein of unknown function (DUF2804) | PF07143 CrtC N‐terminal lipcalin domain; PF17186 Lipocalin‐like domain | 2ichA | 20.2 | 10 | Conserved Trp |
| PF11296 | Protein of unknown function (DUF3097) | Class 2 old family nuclease | 6nk8A | 9.7 | 10 | Conserved Asp, Glu bind Mg |
| PF11443 | Domain of unknown function (DUF2828) | PF05731 TROVE domain – RNA binding protein | 1yvrA | 16.9 | 11 | Large common core (403 residues) |
| PF12038 | Domain of unknown function (DUF3524) | PF13579 Glycosyl transferase 4‐like domain. | 6kihD | 13.5 | 15 | Essential His near UDP at domain interface |
| PF14001 | YdfZ protein. | KOW domain, involved in RNA binding | 5oikZ | 7.7 | 18 | DxxxN, GxxG |
| PF15016 | Domain of unknown function (DUF4520) | PF00659 POLO box duplicated region | 4x9vA | 11.8 | 13 | Structural resemblance |
| PF15025 | Domain of unknown function (DUF4524) | PF00659 POLO box duplicated region | 4xb0A | 9.3 | 11 | Structural resemblance |
| PF15094 | Domain of unknown function (DUF4556). | Zona pellucida sperm‐binding protein | 6gf6B | 5.6 | 12 | Conserved disulfide bridge |
| PF15474 | Meiotically up‐regulated gene family | PF09044 KP4 killer toxin. | 1kptA | 10.2 | 19 | Two conserved disulfide bridges |
| PF15479 | MRN‐interacting protein | PF09082 Domain of unknown function (DUF1922) | 1gh9A | 2.9 | 17 | Conserved CCCC zinc finger |
| PF15866 | Domain of unknown function (DUF4729) | PF03145 Seven in absentia protein family (CL0389( | 4ca1A | 11.5 | 9 | Conserved CCHH zinc finger |
| PF16044 | Domain of unknown function (DUF4796) | PF05903 PPPDE peptidase domain (CL0125) | 3ebqA | 7.6 | 12 | Conserved H, C bind metal ion |
| PF17249 | Family of unknown function (DUF5318) | PF03367 ZPR1 zinc‐finger domain (CL0167) | 2qkdA | 3.6 | 17 | Conserved CCCC zinc finger |
Note: Query family has no structural information in Pfam 35.0; pfamid is hyperlinked to web page visualizing the structural comparison to PDB hit. Protein families of unknown function are highlighted in red.