Table 4.
Generalized linear model for the effect of intervention on regression of LVMI, LVM, and serum vitamin
| Variables at baseline | Model 1: outcome = LVMI | Model 2: outcome = LVM | Model 3: outcome = serum vit D | ||||||
|---|---|---|---|---|---|---|---|---|---|
| B (SE) | 95% CI | P | B (SE) | 95% CI | P | B (SE) | 95% CI | P | |
| Primary analysis | |||||||||
| Intervention | −0.04 (1.80) | (−3.57, 3.49) | 0.981 | 3.17 (4.03) | (−4.73, 11.07) | 0.432 | 8.18 (1.11) | (6.00, 10.35) | <0.001 |
| Age | 0.12 (0.11) | (−0.10, 0.33) | 0.302 | 0.09 (0.25) | (−0.40, 0.58) | 0.714 | 0.16 (0.07) | (0.03, 0.29) | 0.018 |
| Female | 7.11 (2.06) | (3.06, 11.15) | <0.001 | 39.87 (4.62) | (30.81, 48.93) | 0.000 | −0.64 (1.26) | (−3.12, 1.84) | 0.612 |
| BMI | 0.13 (0.11) | (−0.09, 0.35) | 0.243 | 2.15 (0.25) | (1.66, 2.64) | 0.000 | −0.02 (0.07) | (−0.16, 0.11) | 0.749 |
| Smoking | −2.19 (1.78) | (−5.69, 1.30) | 0.219 | −7.38 (3.99) | (−15.20, 0.45) | 0.065 | 1.41 (1.09) | (−0.73, 3.55) | 0.195 |
| Serum vitamin D | −0.50 (0.23) | (−0.94, −0.05) | 0.028 | −1.24 (0.51) | (−2.23, −0.24) | 0.015 | 0.61 (0.14) | (0.34, 0.87) | <0.001 |
| Serum creatinine | 12.97 (4.11) | (4.91, 21.03) | 0.002 | 34.63 (9.21) | (16.58, 52.68) | <0.001 | 2.69 (2.54) | (−2.29, 7.66) | 0.290 |
| Sensitivity analysis† | |||||||||
| Intervention | 0.07 (1.91) | (−3.67, 3.80) | 0.971 | 4.13 (4.23) | (−4.16, 12.41) | 0.329 | 8.63 (1.15) | (6.38, 10.89) | <0.001 |
| Age | 0.08 (0.12) | (−0.15, 0.31) | 0.498 | 0.04 (0.26) | (−0.47, 0.55) | 0.877 | 0.15 (0.07) | (0.01, 0.29) | 0.031 |
| Female | 7.54 (2.24) | (3.15, 11.93) | <0.001 | 39.10 (4.96) | (29.37, 48.83) | <0.001 | −0.30 (1.34) | (−2.94, 2.33) | 0.821 |
| BMI | 0.14 (0.12) | (−0.10, 0.37) | 0.255 | 2.04 (0.27) | (1.52, 2.57) | <0.001 | −0.01 (0.07) | (−0.15, 0.13) | 0.889 |
| Smoking | −2.19 (1.90) | (−5.91, 1.54) | 0.250 | −7.56 (4.22) | (−15.83, 0.70) | 0.073 | 1.42 (1.14) | (−0.81, 3.66) | 0.212 |
| Serum vitamin D | −0.49 (0.24) | (−0.97, −0.01) | 0.045 | −1.17 (0.54) | (−2.23, −0.11) | 0.031 | 0.58 (0.14) | (0.30, 0.86) | <0.001 |
| Serum creatinine | 13.56 (4.31) | (5.12, 22.00) | 0.002 | 37.49 (9.55) | (18.77, 56.21) | <0.001 | 1.92 (2.60) | (−3.18, 7.03) | 0.461 |
Bold text represents values that are statistically significant with P < 0.05.
Note: Analysis performed using long data format. Selected baseline covariates include age, gender, BMI, smoking, serum vitamin D, and serum creatinine. Abbreviations: B, regression coefficient; BMI, body mass index; CI, confidence interval; LVM, left ventricular mass; LVMI, left ventricular mass index; vit D, vitamin D.
†Sensitivity analysis with a subgroup of the sample with deleting cases (19%) who had the supplemental vitamin D in placebo group at baseline.