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. 2021 Dec 30;13(1):60–76. doi: 10.1080/21505594.2021.2018767

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — A. hydrophila-induced mtDNA/caspase-1 axis triggers IL-1β production. HKM pre-incubated with Z-YVAD-FMK, 4-PBA, YCG063 or transfected with sc-siRNA, il1b-siRNA, DNase I, heat-inactivated DNase I, mtDNA were infected with or without A. hydrophila and production of IL-1β protein was measured at 24 h p.i. Vertical bars represent mean ± SE (n = 3). Asterisk indicates significant difference between indicated groups (*p < 0.05). ns indicates not significant between indicated groups. HKM, uninfected HKM; HKM+B, HKM infected with A. hydrophila; HKM+Z-YVAD-FMK+B, HKM pre-incubated with Z-YVAD-FMK infected with A. hydrophila; HKM+4-PBA+B, HKM pre-incubated with 4-PBA infected with A. hydrophila; HKM+YCG063 + B, HKM pre-incubated with YCG063 infected with A. hydrophila; HKM+sc-siRNA, HKM transfected with sc-siRNA; HKM+sc-siRNA+B, HKM transfected with sc-siRNA infected with A. hydrophila, HKM+il1b-siRNA+B, HKM transfected with il1b-siRNA infected with A. hydrophila; HKM+DNase I + B, HKM transfected with DNase I infected with A. hydrophila; HKM+heat-inactivated DNase I + B, HKM transfected with heat-inactivated DNase I infected with A. hydrophila; HKM+mtDNA, HKM transfected with mtDNA.