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. 2022 Dec 13;18(12):e1010545. doi: 10.1371/journal.pgen.1010545

Fig 1. The levels of DNA translocases are reduced at damaged replication forks in PARP1-KO cells.

Fig 1

(A)-(D) Representative images of HLTF, SHPRH, ZRANB3, and SMARCAL1 PLA foci, respectively, in wild-type and PARP1-KO T24 cells. Cells were treated with 0.01% MMS for 1 hour. The association of each protein with replication forks was determined by the SIRF assay. (E)-(H) Distributions of HLTF, SHPRH, ZRANB3, and SMARCAL1 PLA foci derived from a-d, respectively. At least 200 cells from each condition were measured. (Raw SIRF data in S1 Data).