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. 2022 Dec 13;18(12):e1010545. doi: 10.1371/journal.pgen.1010545

Fig 4. ZRANB3 levels are reduced at damaged replication forks in HLTF/SHPRH double-depleted T24 cells.

Fig 4

(A) Representative images of ZRANB3 PLA foci in wild type, HLTF-KO, and HLTF/SHPRH double-depleted T24 cells. Cells were treated with 0.01% MMS for 1 hour. The association of ZRANB3 with replication forks was determined by the SIRF assay. (B) Distribution of ZRANB3 PLA foci derived from a. At least 200 cells from each condition were measured. (C) The number of PLA foci was classified into four groups: 0, 1–5, 6–10, and >11 foci, and the distributions of each group are shown in the plot. (Raw SIRF data in S4 Data).