Skip to main content
. Author manuscript; available in PMC: 2022 Dec 27.
Published in final edited form as: J Investig Med. 2005 Nov;53(7):347–352. doi: 10.2310/6650.2005.53705

FIGURE 3.

FIGURE 3

Effect of inducible nitric oxide synthase (iNOS) inhibitors on systemic nitrate + nitrite (NOx) levels and oxidant stress in New Zealand Black × New Zealand White (NZB/W) mice. Either a specific iNOS inhibitor (l-N6-iminoethyl-lysine [l-NIL], n = 5), a nonspecific iNOS inhibitor (NG-monomethyl l-arginine [l-NMMA], n = 9), or distilled water (n = 7) was administered for 2 weeks to NZB/W mice with active disease. Urine NOx and 8-isoprostane F2α (8-iso-PGF2α) levels were significantly lower in the combined treatment groups when compared with the control group. *p < .05.