Figure 1.

Compared with controls and participants with isolated post-capillary pulmonary hypertension, participants with combined post- and pre-capillary pulmonary hypertension  displayed lower peak VO₂ (A) and less increase in the cardiac output response to exercise (B). Oxygen delivery during exercise was lowest in combined post- and pre-capillary pulmonary hypertension (C), with the highest O₂ extraction (D). Q_T, cardiac output; CpcPH, combined post-and pre-capillary pulmonary hypertension; IpcPH, isolated post-capillary pulmonary hypertension; VO₂, oxygen consumption; DO₂, oxygen delivery. *P < 0.05 vs. controls. †P < 0.05 vs. IpcPH groups.