Figure 6.

PPi rescues the contractility deficit of dilated cardiomyopathy-induced pluripotent stem cell-cardiomyocytes harbouring pathogenic mutations from diverse gene ontologies. (A) Human induced pluripotent stem cells were derived from five dilated cardiomyopathy patients carrying pathogenic mutations in TTN, PLN, LMNA, TPM1, and LAMA2 genes, and two healthy controls. (B–I) Relative contractility analysis of dilated cardiomyopathy-induced pluripotent stem cell-cardiomyocytes treated with PPi or vehicle control (Control). Box-and-whisker plots show the minimum, the 25th percentile, the median, the 75th percentile, and the maximum; n = 6–16 replicates per line from three independent differentiation batches.