Table 2.

Implications of three FRG signatures for MS.

Gene symbol	Full name	Implication	Location
HMOX1	Heme oxygenase 1	HMOX1 may play a significant role in the maintenance of immune homeostasis which is disrupted in autoimmune disorders, such as MS.	Chromosome 22
LPCAT3	Lysophosphatidylcholine acyltransferase 3	Lysophospholipid acyltransferases (LPLATs) regulate the diversification of fatty acid composition in biological membranes. LPCATs are members of the LPLATs that play a role in inflammatory responses.	Chromosome 12
RPL8	Ribosomal protein L8	Neuronal ferroptosis occurs during the acute phase of intracerebral hemorrhage in brain areas distant from the hematoma and that inhibition of ferroptosis by Fer-1 exerted a long-term cerebroprotective effect.	Chromosome 8

MS = multiple sclerosis, FRG = ferroptosis-related gene.