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. Author manuscript; available in PMC: 2023 Dec 15.
Published in final edited form as: Biol Psychiatry. 2022 Jul 5;92(12):942–951. doi: 10.1016/j.biopsych.2022.06.030

Figure 1. Social defeat stress differentially expresses NAc transcriptional patterns in a sex-specific manner.

Figure 1.

Timeline of experiment. Mice were run through social defeat and weeks later, they were run in a social interaction test. The next day, fresh punches of the NAc were collected for RNAseq (A). Social defeat reduces social approach in females but not males during the social interaction test (B). No differences were seen in distance traveled during the open field phase (C). Stressed female mice have different average transcript expression (RPKM) patterns compared to control females (D). Highly enriched differently expressed GO terms identified from overlapping male and female DEGs (E). Minimal overlap is present in DEGs between males and females (F). *planned comparison p<0.05 v. control. Group N’s: males/control: 8, male/stress: 7, female/control: 8, female/stress: 6.