Skip to main content
. Author manuscript; available in PMC: 2023 Dec 15.
Published in final edited form as: Biol Psychiatry. 2022 Jul 5;92(12):942–951. doi: 10.1016/j.biopsych.2022.06.030

Figure 2. Social defeat stress induces similar gene expression patterns in the NAc in female California mice compared to women with major depression (MDD).

Figure 2.

Social defeat stress induces similarities in transcriptional patterns in female California mice compared to transcriptional patterns observed in women with MDD (A); one transcript similarly affected in both data sets is Rgs2. No similarities in DEGs were observed in stressed male California mice and men with MDD (B). Stress reduces Rgs2 average expression in a sex-specific manner (C). Rgs2 expression is correlated to social avoidance behavior in female (D) but not male (E) California mice. *planned comparison p<0.05 v. control. Group N’s: males/control: 8, male/stress: 7, female/control: 8, female/stress: 8, women/MDD: 13, women/control: 9, men/MDD: 13, men/control: 13.