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. 2022 Aug 17;13(2):593–607. doi: 10.1007/s13346-022-01218-2

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Fig. 1 — a DOE (CCD 2³ + 3) set up and minimum (− 1), maximum (+ 1) and intermediate (0) values of independent variables (x) concentration (x₁), needle size (x₂), and spinning time (x₃). b Experimental design and results obtained for dependent variables y₁ (Rf%) and y₂ (Rr%)