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. 2022 Sep 4;13(2):503–519. doi: 10.1007/s13346-022-01226-2

Fig. 1.

Fig. 1

Schematic of manufacturing process for large surface area submicron particle docetaxel (LSAM-DTX). Supercritical carbon dioxide (ScCO2) above the critical point (> 72.8 bar, > 31 °C) is utilized in the manufacturing process. ScCO2 is miscible with organic solvents but a poor solvent for docetaxel which is relatively hydrophobic. Mixing docetaxel in organic solvent with scCO2 causes LSAM-DTX to precipitate into small particles. These small particles are captured in a filter and dried. LSAM-DTX particle size distribution is determined using a validated analytical method in which particles are suspended in 0.01% lecithin in hexane (non-solvent) and analyzed by laser diffraction on a Mastersizer 3000 particle size analyzer (Malvern Panalytical Ltd., Malvern, UK)