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. 2022 Sep 4;13(2):503–519. doi: 10.1007/s13346-022-01226-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — LSAM-taxanes increase intratumoral drug concentrations. Percent drug retained in MDA-MB-231 tumors. All formulations evaluated were prepared at 5-mg/mL concentrations and included suspensions of large surface area microparticle docetaxel (LSAM-DTX), large surface area microparticle paclitaxel (LSAM-PTX) or Abraxane^® (Nab-paclitaxel), or solutions of docetaxel or paclitaxel. Formulations were administered as 0.05-mL direct injections into MDA-MB-231 tumors implanted on the flanks of immunodeficient (NCr-nu/nu) female mice (n = 4 or 5 per group) and tumor tissues were collected 5 days later. The percent of drug retained is based on the concentration of drug detected (ng/g of tumor) and tumor weight divided by the nominal amount of drug delivered (250 ng/injection). Group mean docetaxel percent (blue bars) and paclitaxel percent (red bars) as well as individual animal tumor percents (symbols) are plotted; error bars = ± 1 SD. Adapted with permission from [4]