Fig. 7.

a Group mean tumor volume (TV) from treatment initiation on day 10 through end of study. n = 10 mice/group. All animals survived through day 34 with exception of 1 animal in untreated group which exited study on day 32. Large surface area microparticle docetaxel (LSAM-DTX; ~ 50 mg/kg) and vehicle were dosed intratumoral (IT) (red triangles). Anti-mCTLA-4 (10 mg/kg) was dosed IP (black diamonds). The combination group received both LSAM-DTX and anti-mCTLA-4 on the same schedules as the monotreatments. b Group mean percent change in body weight from treatment initiation through end of study. Error bars =  ± SEM. Significance reported for day 34 vs. no treatment, vehicle controls; ns = not significant, *p < 0.05, **p < 0.01, ****p < 0.0001. c Group median bioluminescence value (photons/second) ± IQR at days 10, 16, and 30. n = 10 mice/group. Significance reported vs. no treatment controls, LSAM-DTX monotherapy; *p < 0.05, **p < 0.01. Significance reported as *p < 0.05, **p < 0.01, ****p < 0.0001. Adapted with permission from [11]