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. 2022 Sep 4;13(2):503–519. doi: 10.1007/s13346-022-01226-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Recurrence free survival (RFS) as a proportion of high-risk non-muscle invasive bladder cancer (NMIBC) subjects in the escalation cohorts 1–3 (n = 10; dotted line) vs. the high dose and expansion cohorts (solid line). Median RFS in the low dose escalation cohorts = 5.4 months vs. 12.2 months in the high-dose and expansion cohorts. Significance (*p < 0.05) determined using Log-rank Mantel-Cox test; hazard ratio (Mantel–Haenszel) = 0.29 with 95% CI = 0.09–0.88. Adapted with permission from [12]