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. 2022 Dec 13;45(12):923–934. doi: 10.14348/molcells.2022.0077

Fig. 1. CYC116 increases the expression of cardiac related genes in H1-derived cardiomyocytes (H1-CMs).

Fig. 1

(A) Schematic representation of experimental timeline and various media used for hESC-H1 culture and cardiomyocyte differentiation and maturation. (B) The expression of Aurora kinase A and Aurora kinase B were significantly decreased during cardiomyocyte differentiation (n = 3). (C and D) FACS analysis of cTnt staining in H1-CMs treated with DMSO or CYC116 (n = 3). (E-G) qRT-PCR analysis of the mRNA levels of genes related to cardiac structure (E), ion channels (F), and mitochondrial functions (G) in H1-CMs treated with DMSO (dashed line) or CYC116 (n = 3). Data are presented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.