Fig. 2. Pathological analysis of lung and spleen in SARS-CoV-2 infected K18-hACE2 mice.

(A and B) H&E stained lungs and spleen sections from mock-infected or 1.0 × 10⁶ PFU SARS-CoV-2 infected mice. Scale bars = 100 μm. (C) To diagnose lung pathology score, inflammation, edema, capillary dilatation, and fibrosis were measured in lung. In spleen, necrosis of white pulp was diagnosed for SARS-CoV-2 derived lesion at 1, 2, 5, and 7 dpi. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.