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. 2022 Nov 2;45(12):896–910. doi: 10.14348/molcells.2022.0089

Fig. 6. Differences between 5-1 group (#4 and #5) and 5-2 group (#3 and #6) that identified by clinical characteristics and spleen pathology.

Fig. 6

(A-D) Analysis of clinical characteristics in SARS-CoV-2 infected K18-hACE2 mice that sacrificed at 5 dpi. Note the body temperature change (A) and body weight loss (B) at 0-7 dpi. Body temperature of 5-1 group was recovered as normal status after 3 dpi. Note the relative tissue weight with body weight (C), and relative spleen weight with body weight (D). BAT, brown-fat adipose tissue; WAT, white-fat adipose tissue. (E and F) Spleen histopathology in SARS-CoV-2 infected K18-hACE2 mice that sacrificed at 5 dpi. Compared with 5-1 group (E), the spleen weight of #3 and #6 was relatively reduced. Severe atrophy and necrosis of white pulp were increased in 5-2 group (F). Scale bars = 200 μm and 100 μm (inset).