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. 2022 Dec 12;45(12):886–895. doi: 10.14348/molcells.2022.2031

Fig. 5. RUNX inhibition by Chb-M’ can be a novel therapeutic strategy for MRT.

Fig. 5

(A) Dose-response curves of Chb, Chb-S, and Chb-M’ in KP-MRT-YM cells. Cells were treated with the indicated concentrations of pyrrole-imidazole (PI) polyamides or Chb. Forty-eight hours after treatment, cell viability was examined using a water-soluble tetrazolium salt (WST) assay (n = 3). (B) Dose-response curves of Chb-M’ in KP-MRT-YM cells transduced with either the lentivirus expressing survivin or control. The cells were simultaneously treated with 3 μM doxycycline and various concentrations of Chb-M. Forty-eight hours after treatment, cell viability was examined using a WST assay (n = 3). Data are represented as the mean ± SEM. *P < 0.05, two-tailed Student’s t-test.