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. 2022 Dec 14;13:973085. doi: 10.3389/fimmu.2022.973085

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Copyright © 2022 Yin, Ling, Wei, He, Wang, Hu, Lin, Nie, Chen, Lin, Zhou, Xie, Yun, Xie, Xue and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan-Meier estimates of overall survival according to the maturation of intratumoral TLSs (log-rank test). (A) Probability of survival of patients in TLS-, Agg, FL-I, and FL-II groups in the SYSUCC cohort. (B) Probability of survival of patients in mature TLSs and non-mature TLSs groups in the SYSUCC cohort. (C) Probability of survival of patients in mature TLSs and non-mature TLSs groups in the SYSUCC cohort, except the patients receiving neoadjuvant chemotherapy patients. (D) Probability of survival of patients in mature TLSs and non-mature TLSs groups in the validation cohort. (E) Probability of survival of patients in mature TLSs^high and mature TLSs^low groups in the SYSUCC cohort. EBVaGC, Epstein-Barr virus associated gastric cancer; TLSs, tertiary lymphoid structures; Agg, Aggregates; FL-I, primary follicles; FL-II, secondary follicles.