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. 2022 Dec 14;13:1026182. doi: 10.3389/fphar.2022.1026182

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Copyright © 2022 He, Feng, Guo, Zhou, Li, Zhang, Zhang, Wang, Wang, Hao, Zhang, Gao, Gu, Zhang, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of BPC157 excretion in rats by examination of total radioactivity. (A) The structure of [³H]-labeled BPC157. [³H]-labeled sites are indicated by T (red). (B) The average recovery of total radioactivity in the urine, feces, cage cleaning fluid, and cadavers during 0–72 h after [³H]BPC157 administration in intact rats (mean ± SD, n = 6). (C) The average recovery of total radioactivity in the urine, feces, and cage cleaning fluid collected during 0–72 h after [³H]BPC157 administration in bile duct cannulated rats (mean ± SD, n = 6). (D) Total radioactivity concentration versus time curve for [³H]BPC157 in jugular vein cannulated rats following a single intramuscular injection at a dose of 100 µg/300 μCi/kg (mean ± SD, n = 6). Data are representative of three independent experiments.