Table 1.
Overview of studies in the relationship between pretreatment serum cystatin C level and renal function in patients with urogenital malignancy.
| Number | Author | Type | Year | Cases | Stage | Treatment | Result | References |
|---|---|---|---|---|---|---|---|---|
| 1 | Duan et al. | RCC | 2017 | 98 | Non-metastatic | Partial Nephrectomy | The predictive value of CysC level at postoperative 6 hours for acute kidney injury was better than that of the intraoperative amount of negative fluid balance and average urine volume. | (47) |
| 2 | Zheng et al. | clear cell RCC | 2020 | 50 | T1N0M0-T2N0M0 | Nephrectomy | Estimation of renal function by serum CysC was weakly correlated with rGFR, but the valuation was low. | (48) |
| 3 | Wenzel et al. | RCC | 2021 | 195 | Non-metastatic | Nephrectomy | Preoperative CysC levels can predict renal impairment after RCC surgery. | (40) |
| 4 | Südfeld et al. | PC | 2016 | 179 | – | Radical prostatectomy | In patients with normal preoperative renal function, administration of a median dose of 1000 ml of hydroxyethyl starch did not result in deterioration of the postoperative CysC-based-renal function. | (23) |
| 5 | Yordanova et al. | PC | 2017 | 55 | Metastatic | [177Lu]Lu-PSMA-617 radioligand therapy | CysC is one of the most reliable predictive markers of nephrotoxicity. | (45) |
| 6 | Yang et al. | PC | 2017 | 173 | All stage | – | CysC levels can predict renal function in prostate neoplasia patients but were not a biomarker for the development of prostate neoplasia and were not correlated with the clinicopathological characteristics of PC. | (24) |
| 7 | Stefanowicz et al. | Wilms tumor | 2010 | 26 | – | Unilateral nephrectomy | CysC levels may be increased in Wilms tumor patients with normal GFR. | (64) |
| 8 | Ichioka et al. | TC | 2017 | 53 | Metastatic | Chemotherapy (cisplatin-based) | eGFR based on CysC may overestimate the renal function in TC survivors cured by cisplatin-based chemotherapy. | (65) |
| 9 | Cameron et al. | TC | 2020 | 53 | – | Chemotherapy (cisplatin-based) | Elevated serum CysC levels may occur early after chemotherapy; they return to baseline levels after 3 months and do not affect long-term renal function. | (66) |
| 10 | Nishimura et al. | UC | 2021 | 18 | – | Chemotherapy (cisplatin-based) | eGFR based on CysC reflected renal function more accurately than eGFR based on Scr. | (68) |
RCC, renal cell carcinoma; PC, prostate cancer; TC, testicular cancer; UC, urothelial carcinoma; CysC, cystatin C; Scr, serum creatinine; eGFR, estimated glomerular filtration rate; rGFR, radionuclide glomerular filtration rate.